Mood disorders including unipolar & bipolar depression & generalized anxiety disorder are exquisitely sensitive to sexual, thyroidal & adrenal hormones. 

At their core the mood disorders involve disturbances in the stress response machinery, operating through the adrenal hormone cortisol.  This hypothalamic mechanism is based upon & sensitive to not only cortisol but also the other small hormones.  It is extremely sensitive to the typically ignored, very high speed upstream effects of the thyroid, sexual & adrenal hormones, such that disturbances in the blends, balances & even the patterns of these small hormones can easily provoke activation of the mood disorders but they equally have the power to frequently relieve them.