Men can more callously steel their hearts against mood swings than can women.

Twice as common in hormonally normal women as in men, unipolar depression is triggered by hormonal shifts, is sex-hormone sensitive & hormone-responsive.

Society has a deep-set bias against the mind as an entity, for obvious reasons such its intangibility & its dependence on non-stop dynamic action. 

Bipolarity is more common in hormonally abnormal women like those with PCOS & hyper-insulinemia. Bipolar disorder involves being mired in a state of depression, then shifting abruptly all the way to mania.

Mood disorders including unipolar & bipolar depression & generalized anxiety disorder are exquisitely sensitive to sexual, thyroidal & adrenal hormones. 

The normal human mind is constantly, dynamically in tune & in sync with reality.