Twice as common in hormonally normal women as in men, unipolar depression is triggered by hormonal shifts, is sex-hormone sensitive & hormone-responsive.

Unipolar depression, where one's moods, far from being unstable are excessively stable, mired in a place of negativity that is difficult to escape, is twice as common in women, not all the time but cropping up during episodes of hormonal flux.  It follows that depression is more commonly seen in women during the stormy teen years, as part of a PMS/PMDD process on a regular monthly basis, in the early weeks & months after delivery in post-partum women, & during the years leading up to menopause, when the sexual hormones are increasingly fluctuant & erratic.  Other hormonal features in the unipolar patient are high cortisol & low testosterone levels.